Intrinsic Pathway−Mediated Apoptosis in Elastase-Induced Aneurysms in Rabbits
نویسندگان
چکیده
منابع مشابه
Intrinsic pathway-mediated apoptosis in elastase-induced aneurysms in rabbits.
BACKGROUND AND OBJECTIVES The pathophysiology of saccular aneurysms is complex and multifactorial. The aim of the present study was to understand the mechanism of apoptosis in an elastase-induced aneurysm model in rabbits. MATERIALS AND METHODS Elastase-induced saccular aneurysms were created at the origin of the right common carotid artery in 20 rabbits. Aneurysm samples were harvested at 2 ...
متن کاملFive-year follow-up in elastase-induced aneurysms in rabbits.
BACKGROUND AND PURPOSE There is no report regarding patency of elastase-induced aneurysms for more than a 2-year period. Our aim was to report aneurysm patency rates up to 5 years in the elastase-induced aneurysm model in rabbits. MATERIALS AND METHODS Twenty-five elastase-induced aneurysms were created in New Zealand white rabbits and followed for up to 5 years. Thirteen (52%) rabbits died d...
متن کاملCreation of bifurcation-type elastase-induced aneurysms in rabbits.
SUMMARY Elastase incubation was performed in the LCCA in 13 New Zealand white rabbits. Three weeks after incubation, DSA demonstrated that 10 (10/13, 77%) bifurcation-type aneurysms at the origin of the LCCA were present; mean aneurysm neck, width, and height values were 3.7 ± 1.1, 3.8 ± 0.9, and 8.7 ± 2.3 mm, respectively. The LCCA can be used to create bifurcation aneurysms in rabbits.
متن کاملElastase-induced saccular aneurysms in rabbits: a dose-escalation study.
BACKGROUND AND PURPOSE Reproducible animal models facilitate preclinical assessment of aneurysm therapies. Our purpose was to determine if increased elastase doses enlarge aneurysms and parent arteries. METHODS Rabbit right common carotid artery (CCA) aneurysms were created with distal ligation and intraluminal elastase incubation. Groups were 1) sham (no elastase, n = 3), 2) 25% elastase (10...
متن کاملElastase-induced saccular aneurysms in rabbits: comparison of geometric features with those of human aneurysms.
BACKGROUND AND PURPOSE The development of more effective intracranial aneurysm therapy depends on the ability to test various intravascular occlusion devices and techniques in preclinical animal models. This requires the creation of experimental aneurysms, which, ideally, should mimic the size and geometric features of human intracranial aneurysms. The purpose of this study was to characterize ...
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ژورنال
عنوان ژورنال: American Journal of Neuroradiology
سال: 2009
ISSN: 0195-6108,1936-959X
DOI: 10.3174/ajnr.a1781